Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.
Bioorg Med Chem Lett
; 15(10): 2481-6, 2005 May 16.
Article
de En
| MEDLINE
| ID: mdl-15863301
ABSTRACT
A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acrylates
/
Protéines virales non structurales
/
Antienzymes
/
Furanes
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2005
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique