Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
Bioorg Med Chem Lett
; 15(10): 2519-22, 2005 May 16.
Article
de En
| MEDLINE
| ID: mdl-15863308
ABSTRACT
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki=0.45 nM).
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Uracile
/
Récepteurs à la gonadolibérine
Limites:
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2005
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique