Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3.
FASEB J
; 19(10): 1302-4, 2005 Aug.
Article
de En
| MEDLINE
| ID: mdl-15928196
ABSTRACT
Peg3 encodes a C2H2 type zinc finger protein that is implicated in a novel physiological pathway regulating core body temperature, feeding behavior, and obesity in mice. Peg3+/- mutant mice develop an excess of abdominal, subcutaneous, and intra-scapular fat, despite a lifetime of lower food intake than wild-type animals. However, they start life with reduced fat reserves and are slower to enter puberty. These mice maintain a lower core body temperature, fail to respond to a cold challenge, and have lower metabolic activity as measured by oxygen consumption. Plasma leptin levels are significantly higher than in wild types, and Peg3+/- mice appear to have developed leptin resistance. Administration of exogenous leptin resulted in a significant reduction in food intake in wild-type mice that was not observed in Peg3+/- mutants. This mutation, which is strongly expressed in hypothalamic tissue during development, has the capacity to regulate multiple events relating to energy homeostasis.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protein kinases
/
Facteurs de transcription
/
Tissu adipeux
Type d'étude:
Etiology_studies
Limites:
Animals
Langue:
En
Journal:
FASEB J
Sujet du journal:
BIOLOGIA
/
FISIOLOGIA
Année:
2005
Type de document:
Article
Pays d'affiliation:
Royaume-Uni