Structural diversity of streptokinase and activation of human plasminogen.
Infect Immun
; 73(7): 4451-3, 2005 Jul.
Article
de En
| MEDLINE
| ID: mdl-15972548
ABSTRACT
The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasminogène
/
Streptokinase
Langue:
En
Journal:
Infect Immun
Année:
2005
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique