Dipeptide nitrile inhibitors of cathepsin K.
Bioorg Med Chem Lett
; 16(9): 2549-54, 2006 May 01.
Article
de En
| MEDLINE
| ID: mdl-16480867
ABSTRACT
A series of dipeptidyl nitriles as inhibitors of cathepsin K have been explored starting from lead structure 1 (Cbz-Leu-NH-CH2-CN, IC50 = 39 nM). Attachment of non-natural amino acid side chains in P1 and modification of the P3 subunit led to inhibitors with higher potency and improved pharmacokinetic properties.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cathepsines
/
Dipeptides
/
Antienzymes
/
Nitriles
Limites:
Animals
/
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2006
Type de document:
Article
Pays d'affiliation:
Suisse