Spontaneous baroreflex cardiac sensitivity in end-stage liver disease: effect of liver transplantation.
Eur J Anaesthesiol
; 23(5): 426-32, 2006 May.
Article
de En
| MEDLINE
| ID: mdl-16507199
ABSTRACT
BACKGROUND AND OBJECTIVE:
End-stage liver disease is associated with an imbalance in the autonomic nervous system. The purpose of this study was to estimate the effect of liver transplantation on this imbalance.METHOD:
The study involved 10 patients undergoing liver transplantation and 9 patients without liver impairment undergoing liver surgery. The spontaneous baroreflex sensitivity was measured before and 1 month after surgery for the liver surgery group; before and 1, 3, 6, 12 and 18 months after orthotopic liver transplantation.RESULTS:
The spontaneous baroreflex slope of patients with end-stage liver disease was decreased before liver transplantation compared to the liver surgery group (3.9 +/- 2.5 ms mmHg(-1) vs. 9.9 +/- 5.0 ms mmHg(-1), P = 0.002). The mean slope was significantly increased at 12 and 18 months compared to the pre-transplantation value (3.9 +/- 2.5 ms mmHg(-1) vs. 8.1 +/- 6.6 ms mmHg(-1) and 7.4 +/- 4.8 ms mmHg(-1), respectively; P = 0.042). Nevertheless, further analysis of individual data showed that only four patients exhibited a marked increase in their baroreflex slope 12 months after the liver transplantation whereas it remained decreased in the six others.CONCLUSIONS:
These results confirm that the baroreflex sensitivity is depressed in end-stage liver disease in line with an autonomic nervous system imbalance. The liver transplantation reverses this disturbance only in some patients.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies du système nerveux autonome
/
Transplantation hépatique
/
Baroréflexe
/
Coeur
/
Maladies du foie
Type d'étude:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur J Anaesthesiol
Sujet du journal:
ANESTESIOLOGIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
France