[Studies on chemical constituents of the brown alga Dictyopteris divaricata].
Zhongguo Zhong Yao Za Zhi
; 31(2): 125-8, 2006 Jan.
Article
de Zh
| MEDLINE
| ID: mdl-16570798
ABSTRACT
OBJECTIVE:
To investigate the chemical constituents of the brown alga D. divaricata, and to test cytotoxicities of the purified compounds.METHOD:
Compounds were isolated by normal phase silica gel, Sephadex LH-20 chromatography and reverse phase HPLC techniques. Their structures were elucidated by spectroscopic methods including IR, MS and NMR. Cytotoxicities were tested by MTT method.RESULT:
Eight compounds were isolated from ethanolic extract of the brown alga D. divaricata and their structures were identified as (-)-torreyol (I), 4beta, 5alpha-dihydroxycubenol (II), 3-farnesyl-p-hydroxybenzioc acid (III), chromazonarol (IV), fucosterol (V), phenyl acetylamine (VI), 4-hydroxybenzoic acid (VII) and n-hexadecanoic acid (VIII).CONCLUSION:
Compound II and IV were obtained from this alga for the first time. The others were isolated from the Dictyotaceae algae for the first time. All compounds were inactive (IC50 > 10 microg x mL(-1)) against human tumor cell lines KB, Bel-7402, PC-3M, Ketr 3 and MCF-7.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Terpènes
/
Xanthènes
/
Phaeophyceae
Limites:
Humans
Langue:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Sujet du journal:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Année:
2006
Type de document:
Article
Pays d'affiliation:
Chine