A common variant associated with prostate cancer in European and African populations.
Nat Genet
; 38(6): 652-8, 2006 Jun.
Article
de En
| MEDLINE
| ID: mdl-16682969
ABSTRACT
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de la prostate
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Type d'étude:
Risk_factors_studies
Limites:
Humans
/
Male
Langue:
En
Journal:
Nat Genet
Sujet du journal:
GENETICA MEDICA
Année:
2006
Type de document:
Article
Pays d'affiliation:
Islande