Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: results of a study in a primary care setting.
World J Gastroenterol
; 12(16): 2569-73, 2006 Apr 28.
Article
de En
| MEDLINE
| ID: mdl-16688803
ABSTRACT
AIM:
To determine the diagnostic value of the rabeprazole test in patients seen by general practitioners.METHODS:
Eighty-three patients with symptoms suggestive of GERD were enrolled by general practitioners in this multi-centre, randomized and double-blind study. All patients received either rabeprazole (20 mg bid) or a placebo for one week. The diagnosis of GERD was established on the presence of mucosal breaks at endoscopy and/or an abnormal esophageal 24-h pH test. The test was considered to be positive if patients reported at least a "clear improvement" of symptoms on a 7-point Likert scale.RESULTS:
The sensitivities of the test for rabeprazole and the placebo were 83% and 40%, respectively. The corresponding specificity, positive and negative predictive values were 45% and 67%, 71% and 71%, and 62% and 35%, respectively. A receiver operating characteristics (ROC) analysis confirmed that the best discriminatory cut-off corresponded to description of "clear improvement".CONCLUSION:
The poor specificity of the proton-pump inhibitor (PPI) test does not support such an approach to establish a diagnosis of GERD in a primary care setting.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Benzimidazoles
/
Oméprazole
/
Reflux gastro-oesophagien
/
Antiulcéreux
Type d'étude:
Clinical_trials
/
Diagnostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
World J Gastroenterol
Sujet du journal:
GASTROENTEROLOGIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
France