Prophylactic and therapeutic use of recombinant activated factor VII in patients with cirrhosis and coagulation impairment.
Dig Liver Dis
; 39(5): 490-4, 2007 May.
Article
de En
| MEDLINE
| ID: mdl-16787769
ABSTRACT
Patients with cirrhosis and impaired coagulation often pose major therapeutic problems during bleeding episodes or invasive procedures. Recombinant activated factor VII (rFVIIa), which has been licensed for the treatment of haemophilia patients with factor VIII or IX inhibitors, has been occasionally used in cirrhotic patients. We present five patients with cirrhosis and coagulopathy who received 1-4 recombinant activated factor VII infusions either prophylactically in order to safely undergo an invasive procedure or therapeutically in order to control a severe bleeding episode which did not respond to standard supportive care. In particular, recombinant activated factor VII infusions were given in two patients before a percutaneous liver biopsy, in one patient before teeth extraction and in two patients with haemoperitoneum after an invasive procedure. Infusions of recombinant activated factor VII achieved rapid correction of prothrombin time in all cases allowing the safe performance of invasive procedures or resulting in efficient control of the bleeding episode. In conclusion, recombinant activated factor VII seems to be a rather promising agent for the prevention or treatment of complications of haemostasis impairment in cirrhotic patients. However, its exact role in this setting needs to be evaluated within well-designed, controlled clinical trials.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles de l'hémostase et de la coagulation
/
Facteur VIIa
/
Cirrhose du foie
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Dig Liver Dis
Sujet du journal:
GASTROENTEROLOGIA
Année:
2007
Type de document:
Article
Pays d'affiliation:
Grèce