Pulmonary metastases from epithelial tumours: late results of surgical treatment.
Eur J Cardiothorac Surg
; 30(2): 217-22, 2006 Aug.
Article
de En
| MEDLINE
| ID: mdl-16828294
ABSTRACT
OBJECTIVE:
Development of distant metastases is one of the primary characteristics of malignant tumours. During the last decades, lung metastasectomy has been progressively accepted as a therapeutic option in oncology patients. The present paper aims to evaluate the long-term results and factors influencing prognosis in patients submitted to lung resection for metastases from extrapulmonary epithelial tumours.METHODS:
We retrospectively analysed data of 202 patients undergoing 207 procedures of lung metastasectomy between January 1980 and December 2003. Factors that may influence long-term prognosis such as completeness of resection, histology of the tumour, disease-free interval, number of resected lesions, involvement of hilar or mediastinal lymph nodes, systemic treatments were investigated.RESULTS:
Complete resection was carried out in 169 patients (83.7%). The more frequent lung resection was sublobar in 67.6% of cases, but rarely in selected patients bilobectomy or pneumonectomy has been carried out too. Perioperative morbidity and mortality were 7.7% and 0.9%. Mean disease-free interval was 49+/-48 months. Mean follow-up was 33+/-31 months, 5-year and 10-year survival rates for completely resected patients were 43% and 17%, respectively. By univariate and multivariate analyses, completeness of resection, disease-free interval of 36 months or more, and single resected metastasis were found to be significant prognostic factors.CONCLUSIONS:
Resection of epithelial lung metastases allows an acceptable prognostic result in appropriately selected patients with very low perioperative morbidity and mortality. Factors such as high disease-free interval, single metastasis and completeness of resection are demonstrated and confirmed to be significantly associated with long-term survival.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pneumonectomie
/
Tumeurs épithéliales épidermoïdes et glandulaires
/
Tumeurs du poumon
Type d'étude:
Evaluation_studies
/
Prognostic_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur J Cardiothorac Surg
Sujet du journal:
CARDIOLOGIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
Italie
Pays de publication:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY