Real-time elastography--an advanced method of ultrasound: First results in 108 patients with breast lesions.
Ultrasound Obstet Gynecol
; 28(3): 335-40, 2006 Sep.
Article
de En
| MEDLINE
| ID: mdl-16909438
ABSTRACT
OBJECTIVES:
To evaluate whether real-time elastography, a new, non-invasive method for the diagnosis of breast cancer, improves the differentiation and characterization of benign and malignant breast lesions.METHODS:
Real-time elastography was carried out in 108 potential breast tumor patients with cytologically or histologically confirmed focal breast lesions (59 benign, 49 malignant; median age, 53.9 years; range, 16-84 years). Tumor and healthy tissue were differentiated by measurement of elasticity based on the correlation between tissue properties and elasticity modulus. Evaluation was performed using the three-dimensional (3D) finite element method, in which the information is color-coded and superimposed on the B-mode ultrasound image. A second observer evaluated the elastography images, in order to improve the objectivity of the method. The results of B-mode scan and elastography were compared with those of histology and previous sonographic findings. Sensitivities and specificities were calculated, taking histology as the gold standard.RESULTS:
B-mode ultrasound had a sensitivity of 91.8% and a specificity of 78%, compared with sensitivities of 77.6% and 79.6% and specificities of 91.5% and 84.7%, respectively, for the two observers evaluating elastography. Agreement between B-mode ultrasound and elastography was good, yielding a weighted kappa of 0.67.CONCLUSIONS:
Our initial clinical results suggest that real-time elastography improves the specificity of breast lesion diagnosis and is a promising new approach for the diagnosis of breast cancer. Elastography provides additional information for differentiating malignant BI-RADS (breast imaging reporting and data system) category IV lesions.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Traitement d'image par ordinateur
/
Tumeurs du sein
/
Mammographie
Type d'étude:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Ultrasound Obstet Gynecol
Sujet du journal:
DIAGNOSTICO POR IMAGEM
/
GINECOLOGIA
/
OBSTETRICIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
Allemagne