The effect of ramipril on left ventricular mass, myocardial fibrosis, diastolic function, and plasma neurohormones in Maine Coon cats with familial hypertrophic cardiomyopathy without heart failure.
J Vet Intern Med
; 20(5): 1093-105, 2006.
Article
de En
| MEDLINE
| ID: mdl-17063701
ABSTRACT
BACKGROUND:
Hypertrophic cardiomyopathy (HCM) is the most common heart disease of cats, resulting in left ventricular (LV) hypertrophy, myocardial fibrosis, and diastolic dysfunction.HYPOTHESIS:
Ramipril will reduce LV mass, improve diastolic function, and reduce myocardial fibrosis in cats with HCM without congestive heart failure (CHF). ANIMALS This prospective, blinded, placebo-controlled study included 26 Maine Coon and Maine Coon cross-bred cats with familial HCM but without CHF.METHODS:
Cats were matched for LV mass index (LVMI) and were randomized to receive ramipril (0.5 mg/kg) or placebo q24h for 1 year, with investigators blinded. Plasma brain natriuretic peptide (BNP) concentration, plasma aldosterone concentration, Doppler tissue imaging (DTI), and systolic blood pressure were measured at baseline and every 3 months for 1 year. Cardiac magnetic resonance imaging (cMRI) was performed to quantify LV mass and myocardial fibrosis by delayed enhancement (DE) cMRI at baseline and 6 and 12 months. Plasma angiotensin-converting enzyme (ACE) activity was measured on 16 cats 1 hour after PO administration.RESULTS:
Plasma ACE activity was adequately suppressed (97%) in cats treated with ramipril. LV mass, LVMI, DTI, DE, blood pressure, plasma BNP, and plasma aldosterone were not different in cats treated with ramipril compared with placebo (P = .85, P = .94, P = .91, P = .89, P = .28, P = .18, and P = .25, respectively).CONCLUSION:
Treatment of Maine Coon cats with HCM without CHF with ramipril did not change LV mass, improve diastolic function, alter DE, or alter plasma BNP or aldosterone concentrations in a relevant manner.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Inhibiteurs de l'enzyme de conversion de l'angiotensine
/
Maladies des chats
/
Ramipril
/
Cardiomyopathie hypertrophique familiale
Type d'étude:
Observational_studies
Limites:
Animals
Langue:
En
Journal:
J Vet Intern Med
Sujet du journal:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique