Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis.
Int J Immunogenet
; 33(6): 423-8, 2006 Dec.
Article
de En
| MEDLINE
| ID: mdl-17117952
ABSTRACT
It has been reported that a functional polymorphism in the promoter of the RANTES gene (-403G/A) is associated with atopic dermatitis in a German population. Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations. We therefore aimed to test whether the RANTES promoter polymorphisms relate to atopic dermatitis in a well-defined Japanese population. We conducted an association study of upregulating promoter polymorphisms of RANTES (-403G/A and -28C/G) in 389 patients with atopic dermatitis and 177 healthy control subjects. There was a significant association between the upregulating variant of RANTES -28G and atopic dermatitis, while -403A variant showed a significant association with atopic dermatitis with high IgE productivity. These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymorphisme génétique
/
Régulation positive
/
Régions promotrices (génétique)
/
Chimiokine CCL5
/
Prédisposition génétique à une maladie
/
Eczéma atopique
Limites:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Int J Immunogenet
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
GENETICA
Année:
2006
Type de document:
Article
Pays d'affiliation:
Royaume-Uni