Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins.
Front Biosci
; 12: 13-21, 2007 Jan 01.
Article
de En
| MEDLINE
| ID: mdl-17127280
ABSTRACT
The mechanisms that permit adult tissues to regenerate are the object of intense study. Liver regeneration is a research area of considerable interest both from pathological and from physiological perspectives. One of the best models of the regenerative process is the two-thirds partial hepatectomy (PH). After PH, the remnant liver starts a series of timed responses that first favor cell growth and then halts hepatocyte proliferation once liver function is fully restored. The mechanisms regulating this process are complex and involve many cellular events. Initiation of liver regeneration requires the injury-related cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), and involves the activation of cytokine-regulated transcription factors such as NF-kappaB and STAT3. An important event that takes place in the hours immediately after PH is the induction of nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2), and the consequent release of nitric oxide (NO) and prostaglandins (PGs). NO is involved in the vascular readaptation after PH, favoring a general permeability to growth factors throughout the organ. This review examines the mechanisms that regulate NO release during liver regeneration and the animal models used to identify these pathways.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Prostaglandines
/
Régénération hépatique
/
Monoxyde d'azote
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Front Biosci
Sujet du journal:
BIOLOGIA
Année:
2007
Type de document:
Article
Pays d'affiliation:
Espagne