Newborn screening levels of 17-hydroxyprogesterone in very low birth weight infants and the relationship to chronic lung disease.
J Pediatr Endocrinol Metab
; 19(9): 1119-24, 2006 Sep.
Article
de En
| MEDLINE
| ID: mdl-17128559
ABSTRACT
OBJECTIVES:
17-Hydroxyprogesterone (17-OHP), an intermediary hormone in cortisol synthesis, has been shown to be elevated in premature infants. However, the relationship between levels of 17-OHP with chronic lung disease (CLD) have not been extensively explored. The objective of this study was to determine whether there is an association between CLD and levels of 17-OHP in a population of very low birth weight infants. STUDYDESIGN:
Cohort study of very low birth weight infants cared for at a single level 3 NICU during a 3-year period from July 2001-July 2004, n=435. Infants had a minimum of one screen for 17-OHP. 17-OHP was measured on the 5th day of life and at 2-4 weeks of life as part of the State of Delaware Newborn Screening Program. Statistical analysis included chi-squared, Pearson correlation, and logistic regression.RESULTS:
Levels of 17-OHP were higher at the time of the 1st screen compared to the 2nd screen (42.2 +/- 36.7 vs 23.5 +/- 32.3 ng/ml, respectively, p = 0.01). After controlling for potential confounding variables, gestational age and prenatal steroids were independently associated with 17-OHP. However, logistic regression analysis showed no association between a 1 log increase in levels of 17-OHP with the outcomes of CLD (odds ratio 1.7, 95% CI 0.7-3.8), or death and/or CLD (odds ratio 2.1, 95% CI 0.9-4.8).CONCLUSIONS:
In our population of very low birth weight infants elevated levels of 17-OHP were not associated with the development of CLD.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dépistage néonatal
/
Nourrisson très faible poids naissance
/
17alpha-Hydroxyprogestérone
/
Maladies pulmonaires
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Aspects:
Patient_preference
Limites:
Female
/
Humans
/
Male
/
Newborn
Langue:
En
Journal:
J Pediatr Endocrinol Metab
Sujet du journal:
ENDOCRINOLOGIA
/
PEDIATRIA
Année:
2006
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique