2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.

Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W; Tam, Steve; Clerin, Valerie; Keith, James C; Tsao, Desirée H H; Sushkova, Natalia; Shaw, Gray D; Camphausen, Raymond T; Schaub, Robert G; Wang, Qin

Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W; Tam, Steve; Clerin, Valerie; Keith, James C; Tsao, Desirée H H; Sushkova, Natalia; Shaw, Gray D; Camphausen, Raymond T; Schaub, Robert G; Wang, Qin.

Affiliation

Kaila N; Chemical and Screening Sciences, Cardiovascular and Metabolic Disease, Drug Safety and Metabolism, Wyeth Research, Cambridge, Massachusetts 02140, USA. nkaila@wyeth.com

J Med Chem ; 50(1): 40-64, 2007 Jan 11.

Article de En | MEDLINE | ID: mdl-17201409

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Quinoléines / Salicylates / Sélectine P / Athérosclérose / Fibrinolytiques / Hydroxyquinoléines Type d'étude: Diagnostic_studies Limites: Animals Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2007 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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