Relevance of 10-min delayed recall in dementia screening.
Eur J Neurol
; 14(2): 144-9, 2007 Feb.
Article
de En
| MEDLINE
| ID: mdl-17250721
ABSTRACT
Within the context of early diagnosis of Alzheimer's disease (AD), there is a growing interest in neuropsychological screening tests. Amongst these tests, we focused on the largely used Memory Impairment Screen (MIS). The objective of the present work was to show that adding a 10-min delayed recall to the MIS, improves the test psychometric characteristics in order to detect dementia in the earliest stages. A prospective study was carried out on a cohort of 270 consecutive elderly ambulatory subjects attending the Broca Hospital Memory Clinic normal controls (n = 67), mild cognitive impairment subjects (n = 98) and mildly demented patients [n = 105, Mini Mental State Examination (MMSE) = 23 +/- 4]. This study consisted in testing the advantage of the 10-min delayed recall entitled MIS-D compared with the MIS. At a cut-off score of 6, the MIS-D revealed satisfying psychometric characteristics with a sensitivity of 81% and a specificity of 91%, whilst the MIS alone indicated a sensitivity of 60% and a specificity of 88% in detecting dementia. In demented patients with MMSE score > or =26, MIS-D properties still remained satisfying (sensitivity 75%, specificity 92%). MIS-D is a more relevant screening test than MIS alone at very early stages of dementia.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rappel mnésique
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Dépistage de masse
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Démence
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Tests neuropsychologiques
Type d'étude:
Diagnostic_studies
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Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limites:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Langue:
En
Journal:
Eur J Neurol
Sujet du journal:
NEUROLOGIA
Année:
2007
Type de document:
Article
Pays d'affiliation:
France