Differential effect of intrastriatal kainic acid on the modulation of dopamine release by mu- and delta-opioid peptides: a microdialysis study.
J Neurochem
; 58(2): 709-13, 1992 Feb.
Article
de En
| MEDLINE
| ID: mdl-1729411
ABSTRACT
The present study investigated the effects of a striatal lesion induced by kainic acid on the striatal modulation of dopamine (DA) release by mu- and delta-opioid peptides. The effects of [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAGO), two highly selective delta- and mu-opioid agonists, respectively, were studied by microdialysis in anesthetized rats. In control animals both opioid peptides, administered locally, significantly increased extracellular DA levels. The effects of DPDPE were also observed in animals whose striatum had been previously lesioned with kainic acid. In contrast to the effects of the delta agonist, the significant increase induced by DAGO was no longer observed in lesioned animals. These results suggest that delta-opioid receptors modulating the striatal DA release, in contrast to mu receptors, are not located on neurons that may be lesioned by kainic acid.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Enképhalines
/
Dopamine
/
2-Alanine-leucine-enképhaline
/
Corps strié
/
Acide kaïnique
Limites:
Animals
Langue:
En
Journal:
J Neurochem
Année:
1992
Type de document:
Article
Pays d'affiliation:
France