Fatal hemophagocytic syndrome related to active human herpesvirus-8/Kaposi sarcoma-associated herpesvirus infection in human immunodeficiency virus-negative, non-transplant patients without related malignancies.
Eur J Haematol
; 78(4): 361-4, 2007 Apr.
Article
de En
| MEDLINE
| ID: mdl-17331129
ABSTRACT
Hemophagocytic syndrome (HS) may occur as a consequence of herpes viral infections. Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus has so far been recognized as a trigger of HS only in immunosuppressed subjects or in patients with Kaposi sarcoma and/or HHV-8-related lymphoproliferative diseases. We report two Italian human immunodeficiency virus (HIV)-negative elderly men who developed an HS with a rapidly fatal course, following treatment with corticosteroids for autoimmune hemolytic anemia. An overwhelming active infection with HHV-8 was unequivocally documented by molecular and immunohistochemical methods, in the absence of HHV-8-related tumors. The occurrence of HHV-8-associated HS, although rare, may be considered, even out of the HIV or the transplantation settings, at least in areas endemic for HHV-8 infection.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infections à Herpesviridae
/
Herpèsvirus humain de type 8
/
Lymphohistiocytose hémophagocytaire
/
Anémie hémolytique auto-immune
Type d'étude:
Diagnostic_studies
/
Risk_factors_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur J Haematol
Sujet du journal:
HEMATOLOGIA
Année:
2007
Type de document:
Article
Pays d'affiliation:
Italie