Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose.
Br J Haematol
; 136(6): 833-6, 2007 Mar.
Article
de En
| MEDLINE
| ID: mdl-17341269
ABSTRACT
We investigated the risk factors for graft-versus-host disease (GVHD) in 82 patients treated with donor lymphocyte infusions (DLI) using an escalating dose regimen for chronic myeloid leukaemia in relapse following conventional allografting. Two factors emerged as predictors of both acute and chronic GVHD the infusion of male recipients with lymphocytes from a female donor and the interval between transplant and last DLI, but only the first remained significant at multivariate analysis. Surprisingly, lymphocyte dose did not influence the incidence of GVHD. Our results suggest that DLI can be given in large cell doses without increasing the risk of GVHD.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Leucémie myéloïde
/
Transfusion de lymphocytes
/
Maladie du greffon contre l'hôte
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Br J Haematol
Année:
2007
Type de document:
Article
Pays d'affiliation:
Royaume-Uni