Atypical mycobacterial spondylitis in HIV-negative patients identified by genotyping.
J Bone Joint Surg Br
; 89(3): 346-8, 2007 Mar.
Article
de En
| MEDLINE
| ID: mdl-17356147
ABSTRACT
Non-tuberculous mycobacterial infections pose a significant diagnostic and therapeutic challenge. We report two cases of such infection of the spine in HIV-negative patients who presented with deformity and neurological deficit. The histopathological features in both specimens were diagnostic of tuberculosis. The isolates were identified as Mycobacterium intracellulare and M. fortuitum by genotyping (MicroSeq 16S rDNA Full Gene assay) and as M. tuberculosis and a mycobacterium other than tuberculosis, respectively, by culture. There is a growing need for molecular diagnostic tools that can differentiate accurately between M. tuberculosis and atypical mycobacteria, especially in regions of the developing world which are experiencing an increase in non-tuberculous mycobacterial infections.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Spondylite
/
Séronégativité VIH
/
Infections à mycobactéries non tuberculeuses
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Aged
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Bone Joint Surg Br
Année:
2007
Type de document:
Article
Pays d'affiliation:
République d'Afrique du Sud