Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes.
Bull Exp Biol Med
; 142(1): 47-50, 2006 Jul.
Article
de En, Ru
| MEDLINE
| ID: mdl-17369900
Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homocysteic acid increased intracellular Ca(2+)concentration, activated of protein kinase C, and induced accumulation of reactive oxygen species, which reflected the involvement of homocysteic acid into cell signaling mechanisms.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes
/
Transduction du signal
/
Récepteurs au glutamate
/
Homocystéine
Limites:
Animals
Langue:
En
/
Ru
Journal:
Bull Exp Biol Med
Année:
2006
Type de document:
Article
Pays de publication:
États-Unis d'Amérique