Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 17(11): 3136-40, 2007 Jun 01.
Article
de En
| MEDLINE
| ID: mdl-17391959
ABSTRACT
We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyrazoles
/
Récepteurs à activité tyrosine kinase
/
Inhibiteurs de protéines kinases
Limites:
Animals
/
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2007
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique