Hepatic and intestinal changes in rats treated with T-0126, a microsomal triglyceride transfer protein (mtp) inhibitor.
J Toxicol Sci
; 32(2): 161-77, 2007 May.
Article
de En
| MEDLINE
| ID: mdl-17538240
ABSTRACT
In the present study, we investigated the potential toxic effects of 2-week oral treatment with T-0126, a novel microsomal triglyceride transfer protein (MTP) inhibitor, on the liver and intestine in male and female rats. Administration of T-0126 decreased serum lipids and resulted in fat accumulation in the liver and the small intestine. In addition, slight changes in the liver, including an increase in serum aminotransferase (AST and ALT) activity, presence of focal inflammatory lesions, and prolongation of PT and APTT were observed after treatment with T-0126. These changes may be related to a mechanism based on malabsorption of fat, fat-soluble antioxidants, and vitamin K, although we cannot exclude other potential mechanisms such as direct cytotoxicity of T-0126.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Benzamides
/
Protéines de transport
/
Indoles
/
Intestin grêle
/
Foie
/
Microsomes
Limites:
Animals
Langue:
En
Journal:
J Toxicol Sci
Année:
2007
Type de document:
Article
Pays d'affiliation:
Japon