Overexpression of interleukin-1beta and interleukin-6 may play an important role in periodontal breakdown in type 2 diabetic patients.
J Periodontal Res
; 42(4): 377-81, 2007 Aug.
Article
de En
| MEDLINE
| ID: mdl-17559636
ABSTRACT
BACKGROUND AND OBJECTIVE:
This study evaluated whether the biochemical changes associated with type 2 diabetes modulate the expression of interleukin-1beta, interleukin-6, interleukin-8, and interferon-gamma in sites with chronic periodontitis. MATERIAL ANDMETHODS:
Biopsies were harvested and divided into three groups group 1, systemically and periodontally healthy subjects (n = 10); group 2, systemically healthy subjects with moderate-to-severe chronic periodontitis (probing depth > 6 mm) (n = 20); and group 3, type 2 diabetic subjects with periodontitis (n = 20). Cytokine levels were assessed in the gingival tissues by enzyme-linked immunosorbent assay analysis.RESULTS:
Data analysis demonstrated that the interleukin-1beta, interleukin-6, interleukin-8, and interferon-gamma levels were higher in the presence of periodontal inflammation than in the absence of inflammation, regardless of systemic status. The interleukin-1beta and interleukin-6 levels were higher in diabetic subjects (group 3) than in systemically healthy patients with comparable types of periodontitis (group 2). No difference was observed for the interleukin-8 and interferon-gamma levels between groups 2 and 3.CONCLUSION:
Within the limits of this study, it was concluded that type 2 diabetes was associated with increased expression of interleukin-1beta and interleukin-6 in periodontally inflamed tissues of diabetic patients, relative to nondiabetic subjects, and that such overexpression may be involved in the mechanisms by which type 2 diabetes enhances periodontal destruction.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies parodontales
/
Interleukine-6
/
Diabète de type 2
/
Interleukine-1 bêta
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Periodontal Res
Année:
2007
Type de document:
Article
Pays d'affiliation:
Brésil