Heparin-induced thrombocytopenia and thrombosis.
Am J Orthop (Belle Mead NJ)
; 36(5): 255-60, 2007 May.
Article
de En
| MEDLINE
| ID: mdl-17571830
ABSTRACT
Heparin-induced thrombocytopenia (HIT) and heparin induced thrombocytopenia with thrombosis (HITT) ar rare complications associated with use of unfractionate heparin (UFH) or low-molecular-weight heparin (LMWH) HIT is a benign clinical condition characterized by a mil drop in platelet count with no clinical significance. HIT is an immune-mediated reaction associated with a wide spread "hypercoagulable" state resulting in arterial an venous thrombosis. There is a higher incidence of HIT with UFH use than with LMWH use. Orthopedic surger patients are at higher risk for developing HITT than are patients who receive prophylactic heparin for cardiovascular surgery or medical reasons. Therapy for patients suspected of having HITT should begin with immedi ate discontinuation of heparin in any form followed by pharmacologic inhibition with thrombin (e.g., recombinant hirudin [lepirudin], argatroban, danaparoid sodium).
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thrombopénie
/
Thrombose
/
Héparine
/
Anticoagulants
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
Am J Orthop (Belle Mead NJ)
Sujet du journal:
ORTOPEDIA
Année:
2007
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique