A new coumarin from the fruits of Coutarea hexandra.
Nat Prod Res
; 21(7): 625-31, 2007 Jun.
Article
de En
| MEDLINE
| ID: mdl-17613820
ABSTRACT
A new 5-O-beta-D-glucopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (1), together with four known compounds, one coumarin, 5-O-beta-D-galactopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (2) and three cucurbitacins, 23,24-dihydrocucurbitacin F (3), 23,24-dihydro-25-acetylcucurbitacin F (4) and 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (5) have been isolated and characterised from the ethanol extract of Coutarea hexandra fruits. Their structures have been established by spectroscopic analysis (NMR and MS). Interpretation of the HMQC, HMBC, COSY-45 and NOESY experiments permitted us to establish stereochemistry of the natural products. All compounds were tested in cytotoxicity assays against the breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rubiaceae
/
Coumarines
Limites:
Humans
Langue:
En
Journal:
Nat Prod Res
Année:
2007
Type de document:
Article