Human muscle-derived cell injection in a rat model of stress urinary incontinence.
Muscle Nerve
; 36(3): 391-3, 2007 Sep.
Article
de En
| MEDLINE
| ID: mdl-17617803
ABSTRACT
We investigated the use of human muscle-derived cells (hMDCs) for the treatment of stress urinary incontinence (SUI) in a nude rat model. hMDCs were isolated from adult skeletal muscle. Three groups of six animals consisting of controls, animals undergoing sciatic nerve transection (SNT) with periurethral sham-injection, and SNT with hMDCs (1 x 10(6) cells/20 microl saline) were utilized. Leak point pressure (LPP) was measured 4 weeks following injection. Bilateral SNT resulted in a significantly lower LPP that was significantly higher following hMDCs than sham injection. The results demonstrate the efficacy of human muscle cell therapy alone in improving physiologic outcomes in an animal model of SUI.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Incontinence urinaire d'effort
/
Fibres musculaires squelettiques
Limites:
Animals
/
Female
/
Humans
Langue:
En
Journal:
Muscle Nerve
Année:
2007
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique