Dietary diphenyl diselenide reduces the STZ-induced toxicity.
Food Chem Toxicol
; 46(1): 186-94, 2008 Jan.
Article
de En
| MEDLINE
| ID: mdl-17870224
ABSTRACT
Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluated whether dietary diphenyl diselenide, a simple synthetic organoselenium compound with antioxidant properties, reduces the streptozotocin (STZ)-induced toxicity. STZ-induced diabetic rats were fed with either standard and diphenyl diselenide (10 ppm) supplemented diets. In experimental trials, dietary diphenyl diselenide significantly decreased mortality rate (p<0.05) induced by STZ treatment. No correlation between this effect and glycemic levels were found. Diphenyl diselenide intake also promoted an increase in vitamin C, -SH levels (liver, kidney and blood) and in catalase (liver and kidney) activity, which were decreased in STZ-treated rats. In enzyme assays, diphenyl diselenide supplementation caused a significant improvement in platelets NTPDase and 5'-nucleotidase activities in STZ-induced diabetic rats when compared to the control and diabetic groups (p<0.05). Nevertheless, this supplementation did not modify the inhibition induced by STZ in delta-ALA-D activity. Our findings suggest that diphenyl diselenide compound showed beneficial effects against the development of diabetes by exhibiting antioxidant properties.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dérivés du benzène
/
Composés organiques du sélénium
/
Diabète expérimental
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Food Chem Toxicol
Année:
2008
Type de document:
Article
Pays d'affiliation:
Brésil