Long-term prognostic value of B-type natriuretic peptide in cardiac and non-cardiac causes of acute dyspnoea.
Eur J Clin Invest
; 37(11): 834-41, 2007 Nov.
Article
de En
| MEDLINE
| ID: mdl-17931382
ABSTRACT
BACKGROUND:
B-type natriuretic peptide (BNP) levels significantly predict increased risk of death in heart failure. The predictive role of BNP levels in patients with non-cardiac causes of acute dyspnoea presenting to the emergency department is not well characterized. MATERIALS ANDMETHODS:
The B-type natriuretic peptide for Acute Shortness of Breath EvaLuation (BASEL) study enrolled consecutive patients with acute dyspnoea.RESULTS:
Cumulative mortality was 14.8%, 33.1% and 51.9% in 452 patients (age 19-97 years; 58% male) within low (< 100 pg mL(-1)), intermediate (100-500 pg mL(-1)) and high (> 500 pg mL(-1)) BNP plasma levels at 18 months of follow-up. BNP classes (point estimate 1.55, 95%CI 1.19-2.03, P = 0.001) in addition to age, increased heart rate and diuretic use emerged as significant predictors for long-term mortality in multivariable Cox regression analyses. The BNP concentration alone had an area under the receiver operating characteristic curve of 0.71 (95%CI 0.66-0.76; P < 0.001) for predicting 18 months mortality. BNP plasma levels independently predicted long-term risk of death in patients with non-cardiac (point estimate 1.72, 95%CI 1.16-2.56; P = 0.007) and with cardiac causes of acute dyspnoea (point estimate 2.21, 95%CI 1.34-3.64; P = 0.002).CONCLUSIONS:
BNP levels are strong and independent predictors for long-term mortality in unselected dyspnoeic patients presenting to the emergency department independent from the cause of dyspnoea.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie coronarienne
/
Peptide natriurétique cérébral
/
Dyspnée
Type d'étude:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur J Clin Invest
Année:
2007
Type de document:
Article
Pays d'affiliation:
Suisse