Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles.
Biomaterials
; 29(6): 675-82, 2008 Feb.
Article
de En
| MEDLINE
| ID: mdl-17996293
ABSTRACT
This study focused at the potential of transforming growth factor beta 1 (TGF-beta 1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-beta1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and were left in place for 4, 8 and 12 weeks. The specimens were evaluated mechanically (push-out test), and morphologically (scanning electron microscopy (SEM), histology, and histomorphometry). The results showed a gradual increase in mechanical strength with increasing implantation periods. Histological and histomorphometrical evaluation showed similar results for both composite formulations regarding histological aspect, new bone formation and bone/implant contact. However, TGF-beta1 loading of the composites demonstrated a significant effect on composite degradation after twelve weeks of implantation. The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ciments osseux
/
Phosphates de calcium
/
Facteur de croissance transformant bêta
/
Fémur
/
Gélatine
Limites:
Animals
Langue:
En
Journal:
Biomaterials
Année:
2008
Type de document:
Article
Pays d'affiliation:
Pays-Bas