Prophylactic antibiotics for the prevention of postpartum infectious morbidity in women infected with human immunodeficiency virus: a randomized controlled trial.
Am J Obstet Gynecol
; 198(2): 189.e1-6, 2008 Feb.
Article
de En
| MEDLINE
| ID: mdl-17997391
ABSTRACT
OBJECTIVE:
The purpose of this study was to determine the effect of intrapartum prophylactic antibiotics in the prevention of postpartum sepsis in laboring women who were infected with HIV. STUDYDESIGN:
In a double-blind, randomized trial that was conducted in Durban (South Africa), pregnant women who were infected with HIV in whom vaginal delivery was anticipated were randomized to receive either a single dose of cefoxitin (2 g) or placebo intrapartum. Signs of sepsis were evaluated within 72 hours and at 1 and 2 weeks postpartum.RESULTS:
Of the 424 women who were enrolled, 213 women received cefoxitin, and 211 women received placebo. Both groups were comparable in all baseline parameters. The overall sepsis rate was 19% (40/211 women) in the placebo group and 16.9% (36/213 women) in the cefoxitin group (P = .581). There was a 53% reduction in risk of postpartum endometritis in the cefoxitin group (95% confidence interval, 0.24-0.9).CONCLUSION:
The use of prophylactic intrapartum cefoxitin in HIV-infected women reduces the risk of postpartum endometritis.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Complications infectieuses de la grossesse
/
Troubles du postpartum
/
Infections à VIH
/
Céfoxitine
/
Endométrite
/
Antibactériens
Type d'étude:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Limites:
Adult
/
Female
/
Humans
/
Pregnancy
Pays/Région comme sujet:
Africa
Langue:
En
Journal:
Am J Obstet Gynecol
Année:
2008
Type de document:
Article
Pays d'affiliation:
République d'Afrique du Sud