Comparison of bioactivities of 5-Fluoro, 5-Iodo, 5-Iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells.
Chem Pharm Bull (Tokyo)
; 56(1): 109-11, 2008 Jan.
Article
de En
| MEDLINE
| ID: mdl-18175988
ABSTRACT
A cell survival assay of the four arabinosyl uridine analogs with functionalities of 5-fluoro, 5-fluorovinyl, 5-iodo, and 5-iodovinyl as potential positron-emitter tagged probe for monitoring cancer gene therapy were performed. Cytotoxicities of 5-fluoro-, 5-iodo-, 5-fluorovinyl, and 5-iodovinyl arabinosyl uridines against SR-39 thymidine kinase transfected murine prostate cancer cells have been evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. None of them showed significant bioactivity. A syn conformation derived from intra-hydrogen bonding was suggested for the unfavorable interaction and diminished bioactivity.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thymidine kinase
/
Uridine
Limites:
Animals
Langue:
En
Journal:
Chem Pharm Bull (Tokyo)
Année:
2008
Type de document:
Article
Pays d'affiliation:
Taïwan