[Non invasive fetal RhD genotyping using maternal blood: time for use in all RhD negative pregnant women]. / Génotypage RhD foetal non invasif sur sang maternel: vers une utilisation chez toutes les femmes enceintes RhD négatif.

ABSTRACT

Non invasive fetal RhD genotyping, based on polymerase-chain-reaction (PCR), is an accurate and validated technique. It allows a reduction by one-third of anti-D immunoglobulin injections to prevent RhD allo-immunization. In case of maternal anti-D immunization, fetal RhD genotyping allows to focus on RhD positive fetuses only the biologic and sonographic follow-up. The wide use of this technique implies the validation and economic evaluation of a commercial RhD genotyping kit, ready for use in non specialized laboratories.