Self-reactive T cells are activated by the 65-kDa mycobacterial heat-shock protein in neonatally thymectomized mice.
Eur J Immunol
; 21(3): 597-603, 1991 Mar.
Article
de En
| MEDLINE
| ID: mdl-1826260
ABSTRACT
To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20 1475), T cells bearing V beta 11-gene products capable of recognizing I-E-encoded molecules were readily detected in the mature T cell pool of NTX BALB/c (I-Ed, Mls-2a) mice. The V beta 11-bearing T cells in NTX mice expressed interleukin 2 receptors and responded normally to signals delivered through the T cell receptor. Notably, these T cells in NTX mice proliferated significantly after culture with the 65-kDa mycobacterial heat-shock protein, whose amino acid sequence is highly homologous to that in eukaryotes. These results suggest that self-reactive T cells in NTX mice may be activated by heat-shock proteins derived from various pathogens and/or stressed autologous cells, resulting in the development of autoimmune diseases in such animals.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes T
/
Antigènes d'histocompatibilité de classe II
/
Auto-immunité
/
Protéines du choc thermique
/
Mycobacterium
/
Antigènes bactériens
Limites:
Animals
Langue:
En
Journal:
Eur J Immunol
Année:
1991
Type de document:
Article
Pays d'affiliation:
Japon