[Characterization of hepatitis B virus strains from the Central African Republic: preliminary results]. / Caractérisation des souches de virus de l'hépatite B circulant en République centrafricaine: résultats préliminaires.
Pathol Biol (Paris)
; 56(5): 310-3, 2008 Jul.
Article
de Fr
| MEDLINE
| ID: mdl-18321662
ABSTRACT
OBJECTIVES:
Genotyping of Hepatitis B virus (HBV) strains from patients in Central African Republic and comparison with results obtained in other African countries. PATIENTS ANDMETHODS:
Sera were collected from patients admitted with symptoms of acute or chronic hepatitis to the "Hôpital de l'Amitié de Bangui", Central African Republic (CAR). The complete sequence of preS2/S gene has been defined for determining genotypes.RESULTS:
Hundred and ninety-six sera were collected from 112 men and 84 women. Ninety-two percent of patients had contact with HBV (anti-HBc postitive) and the HBsAg prevalence was about 62%. HBV DNA was detected in 66% of HBsAg positive sera. No HBV-DNA was evidenced among patients with negative HBsAg. Ninety-three percent of the HBV strains belonged to genotype E; one (3.4%) belonged to genotype A1, and one (3.4%) belonged to genotype D.CONCLUSIONS:
The high prevalence of HBV infection in the studied population is due to their recruitment. The genotype E is predominant in CAR and the intragroup variability of HBV genotype E reached only 1.8%. Genotypes A and D were less common in CAR their presence may be explained by importation.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus de l'hépatite B
/
Hépatite B
Type d'étude:
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Africa
Langue:
Fr
Journal:
Pathol Biol (Paris)
Année:
2008
Type de document:
Article