Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses.
J Perinatol
; 28(7): 468-74, 2008 Jul.
Article
de En
| MEDLINE
| ID: mdl-18432248
ABSTRACT
OBJECTIVE:
To investigate placental expression of insulin-like growth factor-I (IGF-I), fibroblast growth factor-basic (FGF-b) and neural cell adhesion molecule (N-CAM) regarding the pathogenesis of pregnancies with small for gestational age (SGA) fetuses. STUDYDESIGN:
An immunohistochemical analysis using anti-IGF-I, anti-FGF-b and anti-N-CAM antibodies was carried out on 4% paraformaldehyde-fixed placental tissues of third trimester pregnancies complicated with SGA fetuses (n=12) and subjects exhibiting appropriately grown fetuses (n=10). Immunostaining patterns of chorionic villi and amniochorionic membranes were assessed.RESULT:
IGF-I, FGF-b and N-CAM immunostainings in chorionic villi demonstrated significantly increased immunoreactivities in cytotrophoblasts of SGA cases, whereas increased IGF-I immunostaining in syncitiotrophoblasts and increased N-CAM immunostaining in capillary endothelium were noted in the same group. IGF-I, FGF-b and N-CAM immunostainings in amniochorionic membranes revealed significantly decreased IGF-I immunoreactivities in extravillous trophoblasts and increased IGF-I immunoreactivities in decidual cells of SGA cases, while significantly decreased N-CAM immunoreactivities in both decidual cells and extravillous trophoblasts were noted. FGF-b immunostaining revealed no significant differences in both extravillous trophoblasts and decidual cells of SGA cases.CONCLUSION:
Increased placental expression of IGF-I, FGF-b and N-CAM may act in an autocrine and/or paracrine manner to restore the impaired trophoblastic proliferation, migration and metabolism at all gestational stages by means of a positive feedback mechanism.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Placenta
/
Nourrisson petit pour son âge gestationnel
/
Facteur de croissance IGF-I
/
Molécules d'adhérence cellulaire neurales
/
Retard de croissance intra-utérin
/
Facteurs de croissance fibroblastique
Type d'étude:
Observational_studies
Limites:
Adolescent
/
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Langue:
En
Journal:
J Perinatol
Sujet du journal:
PERINATOLOGIA
Année:
2008
Type de document:
Article
Pays d'affiliation:
Turquie