Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.
Bioorg Med Chem Lett
; 18(18): 4952-5, 2008 Sep 15.
Article
de En
| MEDLINE
| ID: mdl-18755587
ABSTRACT
Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyridines
/
Thiophènes
/
Modèles moléculaires
/
Protéines proto-oncogènes
/
MAP Kinase Kinase Kinases
Limites:
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2008
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique