Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice.
Metabolism
; 57(11): 1497-501, 2008 Nov.
Article
de En
| MEDLINE
| ID: mdl-18940385
ABSTRACT
Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Phytostérols
/
Insulinorésistance
/
Matières grasses alimentaires
/
Diabète de type 2
/
Obésité
Type d'étude:
Etiology_studies
Limites:
Animals
Langue:
En
Journal:
Metabolism
Année:
2008
Type de document:
Article
Pays d'affiliation:
Espagne