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Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears.
Szarewski, Anne; Ambroisine, Laurence; Cadman, Louise; Austin, Janet; Ho, Linda; Terry, George; Liddle, Stuart; Dina, Roberto; McCarthy, Julie; Buckley, Hilary; Bergeron, Christine; Soutter, Pat; Lyons, Deirdre; Cuzick, Jack.
Affiliation
  • Szarewski A; Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom. anne.szarewski@cancer.org.uk
Cancer Epidemiol Biomarkers Prev ; 17(11): 3033-42, 2008 Nov.
Article de En | MEDLINE | ID: mdl-18957520
ABSTRACT

BACKGROUND:

The detection of high-risk human papillomavirus (HPV) DNA provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN). This study compared the sensitivity and specificity of several adjunctive tests for the detection of high-grade CIN in a population referred to colposcopy because of abnormal cytology.

METHODS:

953 women participated in the study. Up to seven tests were carried out on a liquid PreservCyt sample Hybrid Capture II (Digene), Amplicor (Roche), PreTect HPV-Proofer (NorChip), APTIMA HPV assay (Gen-Probe), Linear Array (Roche), Clinical-Arrays (Genomica), and CINtec p16INK4a Cytology (mtm Laboratories) immunocytochemistry. Sensitivity, specificity, and positive predictive value (PPV) were based on the worst histology seen on either the biopsy or the treatment specimen after central review.

RESULTS:

273 (28.6%) women had high-grade disease (CIN2+) on worst histology, with 193 (20.2%) having CIN3+. For the detection of CIN2+, Hybrid Capture II had a sensitivity of 99.6%, specificity of 28.4%, and PPV of 36.1%. Amplicor had a sensitivity of 98.9%, specificity of 21.7%, and PPV of 33.5%. PreTect HPV-Proofer had a sensitivity of 73.6%, specificity of 73.1%, and PPV of 52.0%. APTIMA had a sensitivity of 95.2%, specificity of 42.2%, and PPV of 39.9%. CINtec p16INK4a Cytology had a sensitivity of 83.0%, specificity of 68.7%, and PPV of 52.3%. Linear Array had a sensitivity of 98.2%, specificity of 32.8%, and PPV of 37.7%. Clinical-Arrays had a sensitivity of 80.9%, specificity of 37.1%, and PPV of 33.0%.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Papillomaviridae / ADN viral / Dysplasie du col utérin / Infections à papillomavirus Type d'étude: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans Langue: En Journal: Cancer Epidemiol Biomarkers Prev Sujet du journal: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Année: 2008 Type de document: Article Pays d'affiliation: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Papillomaviridae / ADN viral / Dysplasie du col utérin / Infections à papillomavirus Type d'étude: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans Langue: En Journal: Cancer Epidemiol Biomarkers Prev Sujet du journal: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Année: 2008 Type de document: Article Pays d'affiliation: Royaume-Uni