Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women.
Fertil Steril
; 92(6): 1960-5, 2009 Dec.
Article
de En
| MEDLINE
| ID: mdl-18980763
ABSTRACT
OBJECTIVE:
To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS).DESIGN:
Retrospective study.SETTING:
University teaching hospital. PATIENT(S) Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls. MAIN OUTCOME MEASURE(S) Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio. RESULT(S) Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95% CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95% CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95% CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95% CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95% CI, 0.3-0.9). CONCLUSION(S) Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome des ovaires polykystiques
/
Indice de masse corporelle
/
Obésité
Type d'étude:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Female
/
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Fertil Steril
Année:
2009
Type de document:
Article
Pays d'affiliation:
Taïwan