[Endolymph homeostasis and Menière's disease: fundamentals, pathological changes, aminoglycosides]. / Endolymph-Homöostase und M. Menière : Grundlagen, pathologische Veränderungen, Aminoglykoside.
HNO
; 56(12): 1243-52, 2008 Dec.
Article
de De
| MEDLINE
| ID: mdl-19020845
ABSTRACT
Although low dose intratympanal gentamicin has empirically been very effective in treating Menière's disease, the mechanisms of elimination or amelioration of vertigo are still insufficiently understood. Most animal studies investigating the effect of aminoglycosides used high doses that damage or kill hair cells and many other cell types of the inner ear. Additional studies are needed to investigate the effects of low dose gentamicin to elucidate the mechanisms affecting vertigo. In this article it will be explained how disturbances of endolymph homeostasis lead to endolymphatic hydrops and finally to leakage of K(+) from the endolymph into the perilymphatic space. This can lead to a non-physiological activation of vestibular nerve fibres thus causing vertigo.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Endolymphe
/
Maladie de Ménière
/
Modèles biologiques
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
De
Journal:
HNO
Année:
2008
Type de document:
Article
Pays d'affiliation:
Allemagne