Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Acta Neurochir Suppl
; 105: 225-8, 2008.
Article
de En
| MEDLINE
| ID: mdl-19066114
ABSTRACT
Cerebral vasospasm is a major cause of cerebral ischemia and poor outcomes in the setting of aneurysmal subarachnoid hemorrhage (SAH). Despite advances in diagnosis and treatment of SAH, the pathophysiology of vasospasm is still poorly understood and outcomes remain disappointing. Recent advances in understanding the role of hemoglobin in initiating an inflammatory cascade in the subarachnoid space open new avenues for therapy. Preliminary experimental and clinical evidence indicate that targets in the inflammatory and oxidative cascades hold promise in reducing the incidence and impact of cerebral vasospasm.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hémorragie meningée
/
Vasospasme intracrânien
Limites:
Animals
/
Humans
Langue:
En
Journal:
Acta Neurochir Suppl
Année:
2008
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique