Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala.
Nat Neurosci
; 12(2): 141-9, 2009 Feb.
Article
de En
| MEDLINE
| ID: mdl-19136974
ABSTRACT
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches
/
Protéines à homéodomaine
/
Niche de cellules souches
/
Amygdale (système limbique)
/
Neurones
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Animals
/
Pregnancy
Langue:
En
Journal:
Nat Neurosci
Sujet du journal:
NEUROLOGIA
Année:
2009
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique