Concentrations of alpha- and beta-defensins in plasma of patients with inflammatory bowel disease.
Inflamm Res
; 58(4): 192-7, 2009 Apr.
Article
de En
| MEDLINE
| ID: mdl-19184352
ABSTRACT
BACKGROUND:
Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD). MATERIAL ANDMETHODS:
Employing in house radioimmunoassay, we examined concentrations of the major forms alpha-defensins, human neutrophil peptides (HNP) 1-3 and human beta-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn's disease (CD) and 57 controls.RESULTS:
The circulating HNP 1-3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1-3 concentrations in CD patients significantly correlated with Crohn's disease activity index, peripheral white blood cell counts, serum CRP values and TNF-alpha levels.CONCLUSIONS:
Elevation of circulating alpha-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1-3 concentrations may be an indicator for CD activity and their association with CRP and TNF-alpha supports a possible association with the inflammatory process.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies inflammatoires intestinales
/
Défensines-alpha
/
Bêta-Défensines
Limites:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Inflamm Res
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Année:
2009
Type de document:
Article
Pays d'affiliation:
Japon