Differential placental gene expression in severe preeclampsia.
Placenta
; 30(5): 424-33, 2009 May.
Article
de En
| MEDLINE
| ID: mdl-19249095
ABSTRACT
We investigated the global placental gene expression profile in severe preeclampsia. Twenty-one women were randomly selected from 50 participants with uncomplicated pregnancies to match 21 patients with severe preeclampsia. A 30K Human Genome Survey Microarray v.2.0 (Applied Biosystems) was used to evaluate the gene expression profile. After RNA isolation, five preeclamptic placentas were excluded due to poor RNA quality. The series composed of 37 hybridizations in a one-channel detection system of chemiluminescence emitted by the microarrays. An empirical Bayes analysis was applied to find differentially expressed genes. In preeclamptic placentas 213 genes were significantly (fold-change>or=2 and p
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Placenta
/
Pré-éclampsie
/
Régulation de l'expression des gènes au cours du développement
Limites:
Adult
/
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
Placenta
Année:
2009
Type de document:
Article
Pays d'affiliation:
Norvège