Predisposition to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A.
Hum Immunol
; 70(3): 179-83, 2009 Mar.
Article
de En
| MEDLINE
| ID: mdl-19280715
ABSTRACT
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune condition with poorly known etiology, characterized by platelet destruction. Genetic association studies of this disease are scarce, discrepant, and restricted to major histocompatibility complex (MHC) polymorphisms. Hence, a case-control study was conducted with an aim to map the MHC to IPT susceptibility using HLA-B and nine microsatellite loci encompassing MHC class I, II, and III regions. We compared the allelic frequencies in samples of unrelated healthy controls and ITP patients. After correction for multiple tests, only allele MICA*183, also known as A5.1, demonstrated an association, resulting in the identification of a major predisposing region close to STR-MICA. This result may highlight the putative functional role of MICA in the immune response to ITP.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antigènes d'histocompatibilité de classe I
/
Antigènes HLA-B
/
Purpura thrombopénique idiopathique
/
Prédisposition génétique à une maladie
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
America do sul
/
Brasil
Langue:
En
Journal:
Hum Immunol
Année:
2009
Type de document:
Article
Pays d'affiliation:
Brésil