Dendrimers as synthetic gene vectors: cell membrane attachment.
J Chem Phys
; 130(15): 155101, 2009 Apr 21.
Article
de En
| MEDLINE
| ID: mdl-19388769
ABSTRACT
We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain to critical issues arising in emerging gene delivery therapeutic applications, where a molecular carrier is required to deliver DNA segments to the interior of living cells.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Membrane cellulaire
/
Dendrimères
/
Vecteurs génétiques
Langue:
En
Journal:
J Chem Phys
Année:
2009
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique