Children with type 2 diabetes mellitus are at greater risk of macrovascular complications.
Pediatr Int
; 51(4): 563-7, 2009 Aug.
Article
de En
| MEDLINE
| ID: mdl-19419524
ABSTRACT
BACKGROUND:
Type 2 diabetes mellitus (DM) is a risk factor for macrovascular complications in adults. Recently young-onset type 2 DM has increased worldwide and the increase of macrovascular complications in the young is worrisome.METHODS:
Plasma values for plasminogen activator inhibitor-1 (PAI-1) as a marker for promotion, and adiponectin as a marker for inhibition of atherosclerosis, were compared in 33 patients with type 1 DM (16 boys, 17 girls; age 14.9 +/- 3.7 years, mean +/- standard deviation) with those of 43 patients with type 2 DM (15 boys, 28 girls; age 16.5 +/- 3.5 years).RESULTS:
The PAI-1 level was significantly higher (19.3 +/- 8.1 vs 32.9 +/- 17.2 ng/ml; P < 0.001) and the adiponectin level was significantly lower (10.1 +/- 3.8 vs 7.4 +/- 3.7 microg/ml; P < 0.005) in the type 2 DM group. In obese patients, the PAI-1 level was significantly higher (P < 0.005) and the adiponectin level was lower (P= 0.15) in the type 2 DM group. Also, in the non-obese subjects, the PAI-1 level was significantly higher (P < 0.05) and the adiponectin level was lower (P= 0.11) in the type 2 DM group.CONCLUSIONS:
Even in young patients, type 2 DM is a risk factor for macrovascular complications compared with type 1 DM.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Diabète de type 2
/
Angiopathies diabétiques
/
Athérosclérose
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Pediatr Int
Sujet du journal:
PEDIATRIA
Année:
2009
Type de document:
Article
Pays d'affiliation:
Japon